PANCREAZE is clinically proven to improve symptoms of Exocrine Pancreatic Insufficiency (EPI), such as abdominal pain, bloating, diarrhea, and greasy stools.1 It is the only pancreatic enzyme replacement therapy capsule that does not use phthalates as an additive in its formulation.2
The enzymes in PANCREAZE help the body digest food properly and absorb fat, protein, and carbohydrates — which are needed for healthy growth, weight gain, and improved nutritional health.
Learn More About Pancreaze →Watch the video to learn more about how to support your patients with EPI.
If your patient presents with one or more symptoms of abdominal pain, flatulence, steatorrhea, diarrhea, or unexplained weight loss, consider testing for EPI.
PANCREAZE is clinically proven to improve symptoms of EPI and to improve fat and protein absorption
Review the data →All 6 doses of PANCREAZE use a phthalate-free formulation, including the 37,000 lipase unit dose.3 This can be a convenient, appropriate dose for many EPI patients — minimizing the number of capsules they take daily.
Use our Dosing Calculator - a simple tool to help guide individualized dosing.
Use dosing calculator →Eligible patients may pay as little as $0 on their co-pay with the PANCREAZE Savings Card.*
Save up to $2,000 per prescription fill with a maximum yearly benefit of $3,500.*
Learn more about savings →
PANCREAZE is preferred for Cigna HealthcareSM Commercial Formularies‡
For patients not on Cigna plans, use our online Insurance Coverage Lookup and Patient Savings Tool to check their coverage.
† Source: Managed Markets Insight & Technology, LLC, database as of January 2026. Certain plans may require prior authorization.
‡ This is not a guarantee of coverage or payment (partial or full). Actual benefits are determined by each plan administrator in accordance with its respective policy and procedures. Nothing herein may be construed as an endorsement, approval, recommendation, representation or warranty of any kind by any plan or insurer referenced herein.
Eligible patients may pay a minimum of $0 and receive up to $2,000 off the patient's co-pay or out-of-pocket expenses per prescription fill of PANCREAZE (pancrelipase) capsules with a maximum yearly benefit of $3,500. Out-of-pocket expenses may vary. Patient Instructions: In order to redeem the offer, you must have a valid prescription for PANCREAZE. This offer may not be redeemed for cash. By using this offer, you are certifying that you meet the eligibility criteria and will comply with the terms and conditions below. Terms and conditions: Offer is not transferable. Patients are not eligible if they are covered in whole or in part by any state program or federal healthcare program, including, but not limited to, Medicare or Medicaid (including Medicaid managed care), Medigap, VA, DOD, or TRICARE. Only valid in the United States, Puerto Rico, Guam and the U.S. Virgin Islands. Offer void where prohibited by law, taxed, or restricted. Other restrictions may apply. This program is not health insurance. VIVUS LLC has the right to rescind, revoke, or amend this program at any time without notice. Your participation in this program confirms that this offer is consistent with your insurance coverage and that you will report the value received if required by your insurance provider. When you use this card, you are certifying that you understand and will comply with the program rules, terms, and conditions.
PANCREAZE is indicated for the treatment of exocrine pancreatic insufficiency in adult and pediatric patients.
Fibrosing Colonopathy: Associated with high doses, usually over prolonged use and in pediatric patients with cystic fibrosis. Colonic stricture reported in pediatric patients less than 12 years of age with dosages exceeding 6,000 lipase units/kg/meal. Monitor during treatment for progression of preexisting disease. Do not exceed the recommended dosage, unless clinically indicated.
Hyperuricemia has been reported with high dosages; consider monitoring blood uric acid levels in patients with gout, renal impairment, or hyperuricemia.
Irritation of the oral mucosa may occur due to loss of protective enteric coating on the capsule contents.
The presence of porcine viruses that might infect humans cannot be definitely excluded.
Monitor patients with known reactions to proteins of porcine origin. If symptoms occur, initiate appropriate medical management; consider the risks and benefits of continued treatment.
Please read the PANCREAZE Medication Guide and PANCREAZE Product Information and discuss any questions you have with your doctor.
References: 1. References: Trapnell BC, Strausbaugh SD, Woo MS, et al. Efficacy and safety of PANCREAZE for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2011;10(5):350-356. 2. Cystic Fibrosis Foundation. (n.d.). Phthalates. Retrieved from https://www.cff.org/phthalates. 3. PANCREAZE Full Prescribing Information. Campbell, CA: VIVUS LLC; 2024.