PANCREAZE is a combination of porcine-derived lipases, proteases, amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis or other conditions.

37,000 LIPASE UNIT DOSE AVAILABLE.

Try the Pancreaze dosing calculator.

37,000 LIPASE UNIT DOSE AVAILABLE.

Try the Pancreaze dosing calculator.

Resource Center

Download PANCREAZE materials to use in your practice

Select from the following options:

Office Materials

Total Care Rx Pharmacy Overview

VIVUS’ commercial partnership with Total Care Rx offers your PANCREAZE patients a wide variety of personalized services and FREE home delivery. This document describes the personalized services available to your patients.

Total Care Rx Enrollment Form

After providing the prescription, patient and physician information, you can either fax or e-Scribe the completed form to Total Care Rx.

Prior Authorization Materials

Download the Sample Letter of Medical Necessity and the corresponding Medical Necessity Form.

Patient Savings and Financial Support

PANCREAZE Engage Support Program Overview

Help your patients and caregivers understand the comprehensive collection of support services and offers available via the PANCREAZE Engage Support Program.

ENGLISH PDF SPANISH PDF RUSSIAN PDF MANDARIN PDF KOREAN PDF

PANCREAZE Engage Patient Assistance Program Application Form

The PANCREAZE Engage Patient Assistance Program allows eligible patients who are unable to pay for their medication to apply for assistance and receive their medication at no-cost for up to 1 year, after which they may reapply.

Patient Counseling Tools and Discussion Guides

EPI Symptoms Discussion Guide

Consider Exocrine Pancreatic Insufficiency (EPI) in your assessment of GI symptoms and its prevalence in certain subgroups of patients.

Discussion Guide: Could my chronic GI issues be caused by EPI?

This guide can help patients talk with their doctor about what they’re feeling and their medical background.

EPI Symptoms — Bristol Stool Scale

This guide can help facilitate a conversation around the urgent, disruptive symptoms of Exocrine Pancreatic Insufficiency (EPI).

PANCREAZE Product Information

PANCREAZE Patient Brochure

Help patients understand what EPI is and how PANCREAZE can help control their symptoms.

ENGLISH PDF SPANISH PDF RUSSIAN PDF MANDARIN PDF KOREAN PDF

PANCREAZE 37,000 Dosing Guide

PANCREAZE 37,000 can be a convenient, appropriate dose for many EPI patients — minimizing the number of capsules they take daily.

Learn more and access the following:

PANCREAZE HCP Resource Center

Request materials, a rep call, or order samples of the 37,000 unit dose

VISIT THE RESOURCE CENTER

Indication

PANCREAZE is indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis or other conditions.

Important Safety Information

Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement. Exercise caution when doses of PANCREAZE (pancrelipase) exceed 2,500 lipase units/kg body weight per meal (or greater than 10,000 lipase units/kg body weight per day).

Hyperuricemia may develop. Consider monitoring uric acid levels in patients with hyperuricemia, gout, or renal impairment.

To avoid irritation of oral mucosa, do not chew PANCREAZE or retain in the mouth.

There is theoretical risk of viral transmission with all pancreatic enzyme products including PANCREAZE. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.

Most common adverse reactions are: abdominal pain, flatulence, diarrhea, abnormal feces, and fatigue.

PANCREAZE is not interchangeable with any other pancrelipase products.

Dosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Consensus Conferences Guidelines.

Please read the PANCREAZE Medication Guide and PANCREAZE Product Information.

References: 1. PANCREAZE Full Prescribing Information. Campbell, CA: VIVUS LLC; 2022. 2. Trapnell BC, et al. Efficacy and safety of PANCREAZE for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 011;10(5):350-356. 3. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73. 4. Whitcomb, DC, Buchner, AM, Forsmark, CE. AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insuﬃciency: Expert Review. Gastroenterology. 2023;165:1292–1301. 5. Othman MO, Harb D, Barkin JA. Introduction and practical approach to exocrine pancreatic insufficiency for the practicing clinician. Int J Clin Pract. 2018;72:e13066. 6. Crohns and Colitis Foundation (n.d). IBS vs IBD. Retrieved from https:/www.crohnscolitisfoundation.org/what-is-ibd/ibs-vs-ibd 7. Crohns and Colitis Foundation (n.d). Signs and Symptoms of Crohn’s Disease. Retrieved from https://www.crohnscolitisfoundation.org/what-is-crohns-disease/symptoms 8. Kaitha S, Bashir M, Ali T. Iron deﬁciency anemia in inﬂammatory bowel disease. World J Gastrointest Pathophysiol. 2015 August 15; 6(3): 62-72. 9. Perler et al. Presenting symptoms in inﬂammatory bowel disease: descriptive analysis of a community-based inception cohort. BMC Gastroenterology (2019); 19:47. 10. Fousekis FS, Theopistos VI, Katsanos KH, Christodoulou DK. Pancreatic Involvement in Inflammatory Bowel Disease: A Review. J Clin Med Res. 2018;10(10):743-751. 11. Crohns and Colitis Foundation (n.d). Signs and Symptoms of Ulcerative Colitis. Retrieved from https://www.crohnscolitisfoundation.org/what-is-ulcerative-colitis/symptoms 12. Freeman HJ. Iron deficiency anemia in celiac disease. World J Gastroenterol. 2015 August 21; 21(31):9233-9238. 13. Zaidel O, Lin HC. Uninvited Guests: The Impact of Small Intestinal Bacterial Overgrowth on Nutritional Status. Practical Gastroenterology. 2013; Nutrition Issues in Gastroenterology, Series #7: 23-34. 14. Struyvenberg MR, Martin CR, Freedman SD. Practical guide to exocrine pancreatic insufficiency – Breaking the myths. BMC Med. 2017; 15(1): 29. 15. Al-Kaade S (2020, February 3). What causes anemia in exocrine pancreatic insufficiency (EPI)? Medscape. Retrieved from https://www.medscape.com/answers/2121028-18736/what-causes-anemia-in-exocrinepancreatic-insufficiency-epi 16. Vujasinovic M, Valente R, Thorell A, Rutkowski W, Haas SL, Arnelo U, Martin L, Löhr JM. Pancreatic Exocrine Insufficiency after Bariatric Surgery. Nutrients. 2017 Nov 13;9(11):1241. 17. Uribarri-Gonzalez L, Nieto-García L, Martis-Sueiro A, Dominguez-Muñoz JE. Exocrine pancreatic function and dynamic of digestion after restrictive and malabsorptive bariatric surgery: a prospective, cross-sectional, and comparative study. Surg Obes Relat Dis. 2021 Oct;17(10):1766-1772. 18. The National Pancreas Foundation (n.d.). Exocrine Pancreatic Insufficiency (EPI). Retrieved from https://pancreasfoundation.org/patient-information/ailments-pancreas/exocrine-pancreatic-insufficiency-epi/ 19. Cystic Fibrosis Foundation. (n.d.). Phthalates. Retrieved from https://www.cff.org/phthalates. 20. CREON^® Full Prescribing Information. Chicago, IL: Abvie, Inc; 2023. 21. PERTZYE^® Full Prescribing Information. Bethlehem, PA: Digestive Care, Inc; 2022. 22. VIOKACE™ Full Prescribing Information. Birmingham, AL: Allergan USA, Inc; 2012. 23. ZENPEP^® Full Prescribing Information. Bridgewater, NJ: Aimmune Therapeutics, Inc; 2023. 24. Borowitz DS, et al. the Consensus Committee. Use of pancreatic enzyme supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. J Pediatr. 1995; 127:681-84.

Important Safety Information

Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement. Exercise caution when doses of PANCREAZE (pancrelipase) exceed 2,500 lipase units/kg body weight per meal (or greater than 10,000 lipase units/kg body weight per day).

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