PANCREAZE comes in 5 strengths, including the lowest lipase dose on the market1-6
You can individually dose and titrate treatment — right from the start
At lower doses, PANCREAZE has smaller increments than any other PERT available, for more individualized dosing options.1-6 PANCREAZE dosing is consistent with Cystic Fibrosis Foundation Recommendations.1
PANCREAZE Capsule Sizes and Contents
Objects are shown at relative size
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Lipase (USP units) | 2,600 | 4,200 | 10,500 | 16,800 | 21,000 |
Protease (USP units) | 6,200 | 14,200 | 35,500 | 56,800 | 54,700 |
Amylase (USP units) | 10,850 | 24,600 | 61,500 | 98,400 | 83,900 |
Objects are shown at relative size
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Lipase (USP units) |
Protease (USP units) |
Amylase (USP units) |
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2,600 | 6,200 | 10,850 |
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4,200 | 14,200 | 24,600 |
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10,500 | 35,500 | 61,500 |
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16,800 | 56,800 | 98,400 |
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21,000 | 54,700 | 83,900 |
- PANCREAZE recommended starting dose is 500 lipase units/kg of body weight per meal to a maximum of 2,500 lipase units/kg per meal1
- Usually half the prescribed PANCREAZE dose for a full meal should be given with each snack1
- Dose should be individualized based on age, weight, clinical symptoms, degree of steatorrhea and fat content of diet1
- Exercise caution when doses of PANCREAZE exceed 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day)1
- PANCREAZE should be initiated at the lowest recommended dose and gradually increased1
- PANCREAZE is dosed by lipase units and is not interchangeable with any other pancrelipase product1
- Doses greater than 6,000 lipase units/kg of body weight per meal have been associated with colonic strictures, indicative of fibrosing colonopathy, in children with cystic fibrosis less than 12 years of age1
Targeted Dosing — effective dosing strategies will vary by patient
Patients can take PANCREAZE all at once or divide the dose throughout their meal. Splitting the PANCREAZE dose may be an optimal strategy in some adult EPI patients as normal pancreatic secretions occur throughout a meal.9

1. Start
- 1 or more capsules at the beginning of the meal
- To achieve adequate pancreatic enzymes at the same time food is delivered10-12

2. Continue
- 1 or more capsules during the meal
- Acts on food that enters the duodenum from the stomach during this peak digestive period1,10

3. Complete
- 1 or more capsules at the end of the meal
- Continues to aid in digestion, which continues until ~4 hours after meal intake10,12
Pancreatic Enzyme Replacement Therapy (PERT) is reported to be effective for 30 minutes after consumption. For slow eaters or meals extended over a longer duration the total dose required may be split and half given at the commencement of a meal and half during or towards the end.13
How to administer PANCREAZE1

- Swallow capsules whole with sufficient fluid
- Do not crush, chew or retain in the mouth to avoid irritation of the oral mucosa

For Infants
- Administer immediately prior to each feeding
- Do not mix directly with formula or breast milk as this may diminish efficacy

For patients unable to swallow the capsules, contents of the capsule may be sprinkled on small amounts of acidic soft food with a pH <4.5 and consumed within 15 minutes.
- Applesauce (3.10-3.60 pH)
- Crushed blueberries (3.12-3.33 pH)
- Orange or grapefruit juice(3.00-4.19 pH)
- Apricot nectar (3.78 pH)