PANCREAZE is available in six strengths, including a 37,000 lipase unit dose.

PANCREAZE lets you individualize dosing and can be a key for your EPI patients to help with symptom control

  • All 6 doses of PANCREAZE use a phthalate-free formulation.19
  • PANCREAZE is available in 2,600, 4,200, 10,500, 16,800, 21,000 and 37,000 lipase unit capsules.
  • Prescribe PANCREAZE for both meals and snacks — make sure to specify the number of capsules that should be taken per meal and per snack.1

PANCREAZE capsule sizes and contents

PANCREAZE is made up of 2mm diameter microtablets to assist with their mixing with stomach contents and absorption

Objects are shown at relative size

   
  Lipase
(USP units)		 2,600 4,200 10,500 16,800 21,000 37,000  
  Protease
(USP units)		 8,800 14,200 35,500 56,800 54,700 97,300  
  Amylase
(USP units)		 15,200 24,600 61,500 98,400 83,900 149,900  

Objects are shown at relative size

Lipase
(USP units)		 Protease
(USP units)		 Amylase
(USP units)
2,600 8,800 15,200
4,200 14,200 24,600
10,500 35,500 61,500
16,800 56,800 98,400
21,000 54,700 83,900
37,000 97,300 149,900
  • PANCREAZE should be initiated at the lowest recommended dose and gradually increased1
  • At lower doses, PANCREAZE has smaller increments than any other PERT available, for more individualized dosing options1,20-23
  • Doses greater than 6,000 lipase units/kg of body weight per meal have been associated with colonic strictures, indicative of fibrosing colonopathy, in children with cystic fibrosis less than 12 years of age1
  • Exercise caution when doses of PANCREAZE exceed 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day)1
  • Do not substitute other pancreatic enzyme products for PANCREAZE1
  • Dose should be individualized based on age, weight, clinical symptoms, degree of steatorrhea and fat content of diet1
 
 

Optimizing PERT dosing when treating EPI

Effective initial dosing and titration is essential4,29,30

Studies show that patients receiving pancreatic enzyme replacement therapy are frequently underdosed and demonstrate gaps in compliance — with many taking their enzymes solely before or after eating. This can result in complications related to fat malabsorption and malnutrition, having a negative impact on quality of life.

Clinical best practice advice4,29

DOSING BEST PRACTICE ADVICE

PERT should be taken during the meal, with the initial treatment of at least 30,000 - 40,000 USP units of lipase during each meal in adults and one-half of that with snacks. The subsequent dosage can be adjusted based on the meal size and fat content.

WERE YOU AWARE?

A normal pancreas makes approximately 900,000 USP units of lipase during an average meal, with approximately 90,000 units of lipase needed to prevent steatorrhea.